Professor Anthony Brookes’s research interests include genome structure/variation in disease, with a big focus on knowledge management to bridge research and healthcare. Recent impact from such efforts include: the GA4GH standard ‘ADA-M’; GWAS Central; and ‘Café Variome’. Previously he revealed the ‘TUF’ phenomenon which prevents genomic DNA sequences from denaturing; collaborative discovered several disease genes (e.g., PSEN1 in Alzheimer’s Disease); invented the ‘DASH’ method for reading DNA sequences by dynamic hybridisation; and devised novel ‘Megaplex-PCR’ and hybridisation-enrichment technologies.