Safe-and-Sustainable-by-Design (SSbD) advanced materials and chemicals (AdMas&Chems) are a central requirement for reaching the ambitious goal of making Europe the first digitally-enabled circular, climate-neutral and sustainable economy. Such new AdMas&Chems need to provide the high functionality required for their advanced applications, whilst simultaneously exhibiting improved safety and sustainability performances that take into account the complete value chain and life cycle of the material itself and its product(s). To facilitate adoption by industry and, by doing so, foster the twin green and digital transition of Europe’s economy, PINK’s overarching aim is to produce innovative modelling software and integrated workflows that are fully Findable, Accessible, Interoperable and Re-usable (FAIR) to underpin the development of Safe-and-Sustainable-by-Design (SSbD) AdMas&Chems, which are combined into an industry-ready open innovation and decision support platform, the PINK In Silico Hub (PINKISH). The platform will be tested on the real-life needs of industry partners in the PINK Developmental Case Studies and Industrial Demonstrators and iteratively refined / improved.